| GDP dissociation inhibitor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GDI | ||||||||
| Pfam | PF00996 | ||||||||
| InterPro | IPR002005 | ||||||||
| SCOP | 1gnd | ||||||||
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The Guanosine nucleotide dissociation inhibitors (GDIs), bind to the GDP-bound form of Rho and Rab small GTPases and not only prevent exchange (maintaining the small GTPase in an off-state), but also prevent the small GTPase from localizing at the membrane, which is their place of action. This inhibition can be removed by the action of a Guanine nucleotide exchange factor (GEF).
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